assessment, treatment and research of memory and mood disorders

Medicare rebate for TMS
Medicare rebate for TMS treatment is now available for eligible patients from 1 November 2021. Appointments now available in East Melbourne, Brighton, Noble Park, Mount Eliza, Ballarat, and Toowong.
Psychology resources expanded
Appointments available immediately.
New clinic opens in Ballarat
New clinic open at 11 Sturt Street, Ballarat. Psychiatrist and psychologist appointments now available. TMS and Esketamine treatment options available.
NeuroCentrix in Toowong (Qld)
NeuroCentrix is open at 10 Benson St, Toowong. Now accepting psychiatry and psychology referrals. TMS and Esketamine treatment options available. Novel depression treatment as part of a clinical trial coming soon.
TMS at Mt Eliza, Brighton, East Melbourne, Noble Park, and Ballarat clinics
Clinics in Mount Eliza, Brighton, East Melbourne, Noble Park, and Ballarat now offer TMS treatment.
Early access program for Esketamine
The novel depression treatment Esketamine is available to eligible patients in a subsidised early-access program at Noble Park, Ballarat, and Brisbane.
New Praxis clinical trial
NeuroCentrix is now recruiting patients for a potential new treatment for depression at Noble Park.
New clinical trial for Alzheimer's
NeuroCentrix is recruiting patients with memory problems for clinical trials investigating potential new treatments for Alzheimer’s Disease.

Depression Evidence-Based Assessment & Treatment Plans

What is Major Depression?

Major depression is a common mood disorder characterised by persistent feelings of sadness, loss and irritability that lasts for more than two weeks. This can result in a loss of interest and withdrawal from daily activities and social interaction leading to a significant decline in quality of life. Major depression may also affect your memory and concentration. 

Treatment for Major Depression Involves Therapies Across 3 Areas

Biological Therapies
Social Therapies

Effective treatment may involve work in all these areas which should be seen as complementary.

Biological therapies are often required initially in order for you to benefit from psychological treatments. Biological therapies use medication or neurostimulation to normalise brain function.

Psychotherapies involve discussions with a therapist to identify negative patterns of thinking and to provide skills to assist coping with depression.

Social therapies seek to enhance social connectedness, employment and education with improved diet and exercise in a holistic approach to living and engaged an meaningful life.

Common Biological Therapies Include:

  • Antidepressant medications, which work by altering the levels and actions of neurotransmitters in the brain.
  • Transcranial magnetic stimulation (TMS) uses targeted short bursts of magnetic energy applied to specific areas of the brain to normalise the brain’s activity.
Depression Treatments Research

Unfortunately, not every person responds to existing treatments so we are always looking for new alternatives. These research efforts are known as clinical trials.

Clinical trials allow researchers to determine whether new antidepressant therapies work, and to establish their possible risks as well as benefits. In these studies, participants often receive either the trial medication or a placebo for a period of time, during which their response to the medication is monitored regularly.

Participation in a clinical trial is free and participants can withdraw at any time.

Do I Have Depression?

You may be depressed if you have felt sad, low or miserable, most of the time, for more than 2 weeks or have lost interest in activities that would usually bring you pleasure.

Behavioural Signs of Depression

Emotional Signs of Depression

Physical Signs of Depression

What Causes Depression?

The exact cause of depression is not fully understood.

However, a number of factors have been linked to the development of the disorder including:

Life Events

Continuing difficulties and struggles have been linked to depression. This may be long-term unemployment, unhealthy relationships, long-term isolation, or prolonged work stress.

Alternatively, depression could be triggered by a single event such as a childhood trauma, death of a loved one or divorce.

Family History

If a history of depression or another mood disorder runs in your family, then there is an increased risk of developing depression yourself.


You’re at higher risk of developing depression if you have low self-esteem, are self-critical, tend to worry a lot or are perfectionistic.

Medical Illness

Certain conditions, such as insomnia, chronic pain, attention-deficit hyperactivity disorder (ADHD) and many chronic illnesses increase your risk of developing depression.

In addition, certain medication may also increase your risk.

Seek guidance from your doctor if you are concerned.

Drug and Alcohol Use

You are at higher risk of developing depression if you have a history of alcohol or drug misuse.

Interested to participate in a clinical trial?
Contact NeuroCentrix Research Team

Tell us how to contact you

Do You Feel Distressed and Need Urgent Help?